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Transcriptomics identifies genes and signaling pathways that may regulate...

Neuronal death is a normal feature of brain development but also a defining feature of neurodegenerative diseases when improperly regulated. Results of a detailed and comprehensive analysis of...

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Finding points to possible mechanism underpinning Alzheimer's and Parkinson's...

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time discovered a killing mechanism that could underpin a range of the most intractable neurodegenerative...

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Novel culture system replicates course of Alzheimer's disease, confirms...

An innovative laboratory culture system has succeeded, for the first time, in reproducing the full course of events underlying the development of Alzheimer's disease. Using the system they developed,...

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Readying the neural network

Synapse, the name for the signal-receiving site on a neuron, comes from the Greek word for contact. Neuroscientists used to maintain that neurons form one-to-one relationship to contact one another....

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New growth factor indicates possible regenerative effects in Parkinson's disease

Researchers have long sought treatments that can slow the progression of Parkinson's disease. Current treatments have for decades been only symptomatic in nature, supplying the neurotransmitter...

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Scientists identify new drug target to treat ALS

Scientists from the Gladstone Institutes and the University of Michigan have identified a cellular mechanism that can be targeted to treat ALS. The researchers revealed that increasing levels of a...

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Researchers claim modern living may contribute to dementia

Researchers at the University of Bournemouth have published research using death statistics from a group of Western countries suggesting that more people are dying with neurological conditions now than...

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New research sheds light on the molecular origins of Parkinson's disease

As Parkinson's disease progresses in patients, a puzzling dichotomy plays out in their brains. One set of neurons degenerates, while a similar population nearby is spared the same degree of damage. Why...

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Tracing a path toward neuronal cell death

A fruit fly model of a rare, neurodegenerative disease is helping researchers trace the series of steps that lead to neuronal cell death. Damage to astrocytes - star-shaped cells found in the brain and...

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The connection between excess iron and Parkinson's disease

It's long been known that excess iron is found in the brains of patients with Parkinson's disease (PD), an incurable neurodegenerative condition that affects motor function. The mechanism by which the...

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Team suppresses oxidative stress and neuronal death associated with...

The brain  is an enormous network of communication, containing over 100 billion nerve cells, or neurons, with branches that connect at more than 100 trillion points. They are constantly sending signals...

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Loss of MHCI in motor neurons leads to ALS astrocyte toxicity

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating progressive neurodegenerative disease that results in the death of motor neurons, the nerve cells that control...

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Molecular body guards for neurons

In the brain, patterns of neural activity are perfectly balanced. The interplay between activating and inhibitory neurotransmitters ensures that the level of activity stays within the physiological...

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Before retinal cells die, they regenerate, vet blindness study finds

Until relatively recently, the dogma in neuroscience was that neurons, including the eye's photoreceptor cells, rods and cones, do not regenerate. This is the reason that nerve damage is thought to be...

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Promising new compound protects neurons and vision in mice with glaucoma

Early tests of a novel compound in mice with glaucoma should come as welcome news to millions of people around the world now suffering with this leading cause of vision loss. Researchers reporting in...

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Researchers identify new 'druggable' target for sporadic Parkinson's disease

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic...

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Breakthrough in understanding Parkinson's disease

Research from The University of Queensland could lead to a new treatment for Parkinson's disease, with future potential applications to nearly 50 other disorders.

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New strategy to obtain a specific type of amyloid-beta aggregate that may...

The brains of millions of people suffering from Alzheimer's disease are slowly and inescapably being depleted of neurons, but the cause of neuronal death is still unknown. Several studies propose that...

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Saving brain cells from stroke

Researchers from the University of Iowa Carver College of Medicine and the University of Miami Miller School of Medicine have shown that a neuroprotective compound tested in rats provides two-pronged...

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Team identifies mechanism of dopaminergic neuronal death inhibition using...

DGIST's research team has found a candidate substance that can prevent and cure Parkinson's disease. By using this substance, the team also has identified the mechanism of dopaminergic neuronal death...

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In Huntington's disease, traffic jams in the cell's control center kill brain...

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center—the...

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New data network for Huntington's disease research

Huntington's disease is an hereditary disorder of the nervous system caused by a faulty gene on chromosome four. The faulty gene leads to cell death in neurons in the brain resulting in gradual...

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Amyotrophic lateral sclerosis: New clues to the cause and how future drugs...

Scientists have long known that a protein called TDP-43 clumps together in brain cells of people with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, and is associated with...

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Research identifies new brain death pathway in Alzheimer's disease

Alzheimer's disease tragically ravages the brains, memories and ultimately, personalities of its victims. Now affecting 5 million Americans, Alzheimer's disease is the sixth leading cause of death in...

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What is the scope of neurological diseases in the world today?

Globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy etc) has increased substantially over the past 25 years. This problem is the topic of a recent...

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New possibility to prevent and treat Parkinson's disease with licorice extract

DGIST's research team, led by Dr. Yun-Il Lee in Well Aging Research Center, has identified a new mechanism to inhibit dopaminergic neuronal apoptosis, a possible approach for preventing and treating...

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Understanding the molecular mechanisms of amyotrophic lateral sclerosis

Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step toward controlling progression of the disease.

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Researchers identify new melatonin-based molecular targets that will allow to...

A team of scientists led by Darío Acuña-Castroviejo, professor at the University of Granada (UGR), has published the results of a new breakthrough in molecular mechanisms of the anti-Parkinsonian...

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These carbon dioxide-sensing neurons wake up mice

Stimulating a population of neurons in the midbrain with carbon dioxide (CO2) awakens adult male mice without enhancing breathing, finds a study published in JNeurosci. These findings are relevant to...

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Altering Huntington's patients' skin cells into brain cells sheds light on...

Scientists at Washington University School of Medicine in St. Louis have transformed skin cells from patients with Huntington's disease into the type of brain cell affected by the disorder. The...

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